params <- c(
BODYWT =0.3517, #body weight (kg)
MW = 505, #molecular weight for DLM (g/mole)
FuPLS=0.2, #unbound fraction in plasma
LYMPHSWTCH =1, #switch for lymphatic absorption
KMF = 10, #empirical adjustment factor for decreased free concentration
KA = 0.31, #absorption rate constant from lumen (1/hr)
KLV=0.000026, #equilibrium between corn oil and lumen (1/hr)
KVL=0.2, #equilibrium between corn oil and lumen (1/hr)
KFEC=0.025, #Fecal excretion rate constant (1/hr)
PDOSE =0.0, #oral dose (mg/kg)
IVDOSE = 0.0, #IV dose (mg/kg)
IVTLEN=0.01, #IV duration (hr)
VOLBLOODC = 0.074, #fraction of bodyweight to blood volume
VOLADIPC = 0.0513, #fraction of bodyweight to fat
VOLBRAINC = 0.005587, #fraction of bodyweight to brain
VOLLIVERC =0.0387, #fraction of bodyweight to liver
VOLRPC = 0.0155, #fraction of bodyweight to rapidly-perfused tissue
VOLBONEC = 0.073, #fraction of bodyweight to GI
VOLROBC = 0.057, #fraction of bodyweight to to bone
VOLGIC = 0.0437, #fraction of bodyweight to rest of body
VTBC = 0.05, #fraction of tissue volume in diffusion-limited tissues
CARDOUTPC =3.1197, #total plasma flow (L/hr)
HCT = 0.45, #hematocrit
FRADIPC = 0.07, #fraction of total plasma flow to fat
FRBRNC =0.02, #fraction of total plasma flow to brain
FRLIVC = 0.183, #fraction of total plasma flow to liver (portal + hepatic arterial blood)
FRLIVH = 0.05, #fraction of total plasma flow to hepatic arterial
FRSPC = 0.15, #fraction of total plasma flow to slowly-perfused tissue
PBRN= 0.44, #brain PC
PADIP= 68.7, #fat PC
PLIV = 1.71, #liver PC
PRP = 1.71, #rapidly-perfused tissue PC
PSP =3.94, #slowly-perfused tissue PC
PGI = 1.71, #GI PC
PAFC=1.5, #fat permeability-area cross product (L/hr/kg^0.75)
PASPC=0.05, #slowly-perfused tissue permeability-area cross product (L/hr/kg^0.75)
PABC =0.095, #brain permeability-area cross product (L/hr/kg^0.75)
VCYPC = 3279.85, #Vmax for liver CYP (umol/hr/kg)
VCAEMC=294.59, #Vmax for liver microsomal CES (umol/hr/kg)
VCAECC=373.40, #Vmax for liver cytosolic CES (umol/hr/kg)
VPLSC=1986.9, #Vmax for plasma CES (umol/hr/kg)
KMCYP=0.76, #Km for liver CYP (umol/ml)
KMCAEM=0.76, #Km for liver microsomal CES (umol/ml)
KMCAEC=0.93, #Km for liver cytosolic CES (umol/ml)
KMPLS=1.79 #Km for plasma CES (umol/ml)
)