params <- c(
BODYWT =0.3517, 		#body weight (kg)
MW = 505,       		#molecular weight for DLM  (g/mole)    
FuPLS=0.2,      		#unbound fraction in plasma
LYMPHSWTCH =1,  		#switch for lymphatic absorption   
KMF = 10,         	#empirical adjustment factor for decreased free concentration
KA = 0.31,        	#absorption rate constant from lumen (1/hr)
KLV=0.000026,     	#equilibrium between corn oil and lumen (1/hr)
KVL=0.2,         		#equilibrium between corn oil and lumen (1/hr)
KFEC=0.025,       	#Fecal excretion rate constant (1/hr)
PDOSE =0.0,       	#oral dose (mg/kg)
IVDOSE = 0.0,     	#IV dose (mg/kg)
IVTLEN=0.01,      	#IV duration (hr)
VOLBLOODC =  0.074,     #fraction of bodyweight to blood volume
VOLADIPC =  0.0513,     #fraction of bodyweight to fat 
VOLBRAINC = 0.005587,   #fraction of bodyweight to brain
VOLLIVERC =0.0387,      #fraction of bodyweight to liver
VOLRPC = 0.0155,        #fraction of bodyweight to rapidly-perfused tissue
VOLBONEC = 0.073,       #fraction of bodyweight to GI
VOLROBC = 0.057,        #fraction of bodyweight to to bone
VOLGIC = 0.0437,        #fraction of bodyweight to rest of body
VTBC = 0.05,		#fraction of tissue volume in diffusion-limited tissues
CARDOUTPC =3.1197, 	#total plasma flow (L/hr)
HCT = 0.45, 		#hematocrit
FRADIPC = 0.07,		#fraction of total plasma flow to fat
FRBRNC =0.02,		#fraction of total plasma flow to brain
FRLIVC = 0.183, 		#fraction of total plasma flow to liver (portal + hepatic arterial blood)
FRLIVH = 0.05,		#fraction of total plasma flow to hepatic arterial
FRSPC = 0.15, 		#fraction of total plasma flow to slowly-perfused tissue
PBRN= 0.44, 		#brain PC
PADIP= 68.7,     	 	#fat PC
PLIV = 1.71,  		#liver PC
PRP = 1.71, 		#rapidly-perfused tissue PC
PSP  =3.94, 		#slowly-perfused tissue PC
PGI = 1.71,  		#GI PC
PAFC=1.5,  	      	#fat permeability-area cross product (L/hr/kg^0.75)   
PASPC=0.05,       	#slowly-perfused tissue permeability-area cross product (L/hr/kg^0.75)
PABC =0.095, 		#brain permeability-area cross product (L/hr/kg^0.75)
VCYPC = 3279.85, #Vmax for liver CYP  (umol/hr/kg)
VCAEMC=294.59,     #Vmax for liver microsomal CES (umol/hr/kg)
VCAECC=373.40,   #Vmax for liver cytosolic CES (umol/hr/kg)
VPLSC=1986.9,    #Vmax for plasma CES (umol/hr/kg)
KMCYP=0.76,      #Km for liver CYP (umol/ml)
KMCAEM=0.76,     #Km for liver microsomal CES (umol/ml)
KMCAEC=0.93,     #Km for liver cytosolic CES (umol/ml)
KMPLS=1.79       #Km for plasma CES (umol/ml)
 )